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연세암센터 홈페이지




교육 및 임상 경력

1974-1978 연세대학교 세브란스병원 내과 인턴, 레지던트
1981-1983 연세대학교 의과대학 내과학교실 전임강사
1983-1986 Fellow in Medicine Oncology Vincent T. Lombardi Cancer Research Center, Georgetown University, School of Medicine, Washinton, D.C.
1983-1989 연세대학교 의과대학 내과학교실 조교수
1989-1995 연세대학교 의과대학 내과학교실 부교수
1993-1998 연세의료원 암센터 종양학과장
1995-현재 연세대학교 의과대학 내과학교실 교수
1998-2004 연세의료원 암센터 진료부장
1998-2004 연세대학교 의과대학 암연구소 소장
2000-2010 암전이연구센터 소장

학술관련경력

대한소화기병학회 평회원
American Society of Clinical Oncology 평회원
대한내과학회 평회원
American Association for Cancer Research 평회원
1989-1992 대한암학회 총무이사
1992-1996 대한두경부종양학회 총무이사
1992-2000 보건복지부 중앙약심 신약임상시험평가위원회 위원
1993-1998 보건복지부 국립암센터 건립추진자문위원회 자문위원
1993-1998 대한임상약리학회 상임이사
1994-1996 보건복지부 신약임상시험평가위원회 위원장
1994-1999 보건복지부 암정복추진기획단 추진 자문위원
1995-1998 대한암협회 총무이사
1996-2002 대한 암학회 상임이사
1997-2006 대한 두경부종양학회 상임이사
1998-2000 보건복지부 중앙약사심의위원회 위원
1998-2000 대한암학회 학술이사
2002-2006 대한암학회 감사
2003-2005 제18차 아세아 태평양 암학회(18th APCC Seoul) 조직위원장 Asia & Pacific Federation of Oganization for Cancer Research & Control(APFOCC) 회장
2006-2007 Cancer Therapeutics Research Group(CTRG) 회장
2006-2008 건강심사평가원 암질환심의위원회 제1기 위원
2006-2008 대한암학회 이사장
2001-현재 Council Member of the Executive Committee & Treasurer,Asia & Pacific Federation of Organization for Cancer Research & Control(APFOCC)
2003-현재 Council Member, Asia Pacific Medical Education Initiative for Molecular Targeted Therapy of Cancer(MTTC)
2005-2011 한국과학기술단체총연합회 부회장(보건부문)
2008-2011 국가 생명윤리 심의위원회 위원장
2011-현재 원자력의학원 이사

*수상경력
근정포장 제 82246 호 2008년 11 월 27 일

주요 관심분야

신약개발 및 임상연구(New Drug Development and Clinical Trial)
암전이 및 혈관생성(Cancer Metastasis and Angiogenesis)

학력사항

연세대학교 의학과 학사(1973)
연세대학교 의학과 석사(1977)
연세대학교 의학과 박사(1990)


논문


국소진행성 직장암에서 수술전 방사선 및 항암화학 동시요법의 효과
대한방사선종양학회지(Journal Of The Korean Society For Therapeutic Radiology And Oncology) 18 4:293~299,2000


위암에서 ex vivo Model 을 이용한 MMP - 9 에 대한 Gabexate Mesylate IC50의 응용 : 예후인자 및 치료대상 선정기준
대한암학회지 32 1:7~18,2000


유방암 조직에서 Urokinase - type Plasrninogen Activator Receptor 발현의 임상적 의의
대한암학회지 32 1:53~59,2000


Correlation of tissue and blood plasminogen activation system in breast cancer
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY 150 0:137~145,2000


E1B 55kD 유전자 결손 아데노바이러스의 종양 특이 증식 및 살상능 검증.
대한암학회지 :~,2000


Enhancement of gene transfer efficiency into human cancer cells by modification of retroviral vectors and addition of chemicals
ONCOLOGY REPORTS 7 0:119~124,2000


Neoadjuvant Chemotherapy and Radiation for Inoperable cacinoma of the Maxillary Antrum: A matched-control study.
COMPUTER GRAPHICS WORLD 23 3:301~308,2000


Tissue urokinase-type plasminogen activator receptor levels in breast cancer
International J Mol Medicine 6 0:301~305,2000


Transduction effect of antisense K-ras on malignant phenotypes in gastric cancer cells
CANCER LETTERS 157 1:1~7,2000


Angiocentric lymphoma of the head and neck: Patterns of systemic failure after radiation treatment
JOURNAL OF CLINICAL ONCOLOGY 18 1:54~63,2000


진행성 직장암에서 수술후 보조 치료법으로 5-Fluorouracil의 경정맥 투여와 Doxifluridine의 경구투여에 대한 전향적 임의비교연구
대한외과학회지 60 2:195~199,2001


Early post-operative intraperitoneal chemotherapy with mitomycin-C, 5-fluorouracil and cisplatin for advanced gastric cancer
ONCOLOGY 60 1:24~30,2001


Efficacy of Pre - and Postoperative Chemotherapy in Patients with Osteosarcoma of the Extremities
대한암학회지 33 6:520~526,2001


Intravenous 5-fluorouracil versus oral doxifluridine as pre-operative concurrent chemoradiation for locally advanced rectal cancer: prospective randomized trials.
JAPANESE JOURNAL OF CLINICAL ONCOLOGY 31 0:25~29,2001


Leptomeningeal Carcinomatosis in Solid Tumors ; Clinical Manifestation and Treatment
대한암학회지 33 1:34~40,2001


Monthly 5-days 5-fluorouracil and low-dose leucovorin for adjuvant chemotherapy in colon cancer.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY 167 2:215~224,2001


Squamous Cell Carcinoma of the Cornea
YONSEI MEDICAL JOURNAL 42:576~579,2001


Efficacy of Pre- and Postoperative Chemotherapy in Patients with Osteosarcoma of the Extremities
Cancer Research and Treatment 33 6:520~526,2001


Clinical lmplication of functional genomics in cancer.
BIOCHEMISTRY NEWS :~,2002


Low dose and slow titration of topiramate as adjunctive therapy in refractory partial epilepsies: a multicentre open clinical trial
Seizure 11 4:255~260,2002


Suppression of peritoneal metastasis by expression of murine endostatin cDNA
CANCER RESEARCH AND TREATMENT 34 4:302~307,2002


동소이식을 이용한 위암의 전이모델.
대한외과학회지 :~,2002


A case of paraneoplastic nephrotic syndrome in a patient with ovarian carcinoma
YONSEI MEDICAL JOURNAL 44 3:539~543,2003


Infusional 5-flurouracil, leucovorin and docetaxel in advanced gastric cancer
CANCER RESEARCH AND TREATMENT 35 0:123~129,2003


Adeno-associated virus mediated endostatin gene therapy in combination with topoisomerase inhibitor effectively controls liver tumor in mouse model
WORLD JOURNAL OF GASTROENTEROLOGY 10 8:1191~1197,2004


Angiocentric T-cell and NK/T-cell lymphomas: Radiotherapeutic viewpoints
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS 59 4:1127~1137,2004


Lack of correlation between P-glycoprotein and chemotherapy resistance in nasal NK/T-cell lymphomas
LEUKEMIA & LYMPHOMA 45 9:1857~1864,2004


Clinical relevance of three subtypes of primary sinonasal lymphoma characterized by immunophenotypic analysis
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK 26 7:584~593,2004


Tumor Volume Change after Chemotherapy as a Predictive Factor of Disease Free Survival for Osteosarcoma
YONSEI MEDICAL JOURNAL 46 1:119~124,2005


원발성 종격동 림프종의 임상상 및 치료 성적
대한내과학회지(korean Journal of medcine) 68 4:417~426,2005


Gemcitabine monotherapy as salvage chemotherapy in heavily pretreated metastatic breast cancer
BREAST CANCER RESEARCH AND TREATMENT 90 3:215~221,2005


Treatment of Hodgkin's Disease : A Twenty-Year Follow Up Experience of a Single Center in Korea
YONSEI MEDICAL JOURNAL :~,2005


cDNA 미세배열 비교게놈교잡법 (cDNA microarray-based comparative genomic hybridization)을 이용한 염색체 이상 질환의 최신 고속 산전 유전 진단
대한산부인과학회지(Korean Journal of Obstetrics and Gynecololy) 48 7:1621~1634,2005


Different role of functional domains of hTR in DNA binding to telomere and telomerase reconstruction
FEBS LETTERS 579:127~132,2005


A pilot study of trans-arterial injection of 166Holmium-Chitosan complex for treatment of small hepatocellular carcinoma
YONSEI MEDICAL JOURNAL 46 6:799~805,2005


Thymidine phosphorylase suppresses apoptosis induced by microtubule-interfering agents
BIOCHEMICAL PHARMACOLOGY 70:13~21,2005


Oncologic outcomes after neoadjuvant chemoradiation followed by curative resection with tumor-specific mesorectal excision for fixed locally advanced rectal cancer: Impact of postirradiated pathologic downstaging on local recurrence and survival
ANNALS OF SURGERY 244 6:1024~1030,2006


영성 증진 중재가 암환자의 영성, 사회적 지지 및 투병정신에 미치는 효과
Journal of Korean Academy of Adult Nursing(성인간호학회지) 18 2:240~250,2006


Long-term Survival after Surgical Resection for Liver Metastasis from Gastric Cancer: Two Case Reports
CANCER RESEARCH AND TREATMENT 38 3:184~188,2006


Treatment of Hodgkin's disease: A twenty-year follow-up of patients at a center in Korea
YONSEI MEDICAL JOURNAL 47 4:455~465,2006


Protection against DNA damage-induced apoptosis by the angiogenic factor thymidine phosphorylase
FEBS LETTERS 580:1294~1302,2006


A phase II study of infusional 5-fluorouracil and low-dose leucovorin with docetaxel for advanced gastric cancer
ONCOLOGY 70:63~70,2006


A phase II trial of S-1 monotherapy in metastatic colorectal cancer after failure of irinotecan- and oxaliplatin-containing regimens
BRITISH JOURNAL OF CANCER 95:1637~1641,2006


A phase II trial of weekly fractionated irinotecan and cisplatin for advanced gastric cancer
CANCER CHEMOTHERAPY AND PHARMACOLOGY 59:313~320,2007


A phase II study of S-1 monotherapy administered for 2 weeks of a 3-week cycle in advanced gastric cancer patients with poor performance status
BRITISH JOURNAL OF CANCER 97:458~463,2007


Bilateral breast cancer: Differential diagnosis using histological and biological parameters
JAPANESE JOURNAL OF CLINICAL ONCOLOGY 37:487~492,2007


Irofulven as first line therapy in recurrent or metastatic gastric cancer: a phase II multicenter study by the Cancer Therapeutics Research Group (CTRG)
CANCER CHEMOTHERAPY AND PHARMACOLOGY 59:295~300,2007


An association between RRM1 haplotype and gemcitabine-induced neutropenia in breast cancer patients
ONCOLOGIST 12:622~630,2007


Changing patterns of prognosticators during 15-year follow-up of advanced gastric cancer after radical gastrectomy and adjuvant chemotherapy: A 15-year follow-up study at a single korean institute
ANNALS OF SURGICAL ONCOLOGY 14:2730~2737,2007


Cetuximab rescue a patient with non-small cell lung cancer from rapid disease progression during chemotherapy
ACTA ONCOLOGICA 46 4:547~549,2007


Phase I trial of neoadjuvant concurrent chemoradiotherapy with S-1 and weekly irinotecan in locally advanced rectal cancer
Radiotherapy And Oncology 87:361~366,2008


Capecitabine and doxorubicin combination chemotherapy as salvage therapy in pretreated advanced gastric cancer
Cancer Chemotherapy And Pharmacology 61:157~165,2008


The combination of capecitabine and irinotecan in treating 5-Fluorouracil- and Oxaliplatin-pretreated metastatic colorectal cancer
Cancer Chemotherapy And Pharmacology 61:75~81,2008


Chemoradiotherapy with or without consolidation chemotherapy using cisplatin and 5-fluorouracil in anal squamous cell carcinoma: Long-term results in 31 patients
Bmc Cancer 8:~,2008


A phase II study of paclitaxel combined with infusional 5-fluorouracil and low-dose leucovorin for advanced gastric cancer
Cancer Chemotherapy And Pharmacology 61:315~321,2008


Phase III trial of adjuvant 5-fluorouracil and adriamycin versus 5-fluorouracil, adriamycin, and polyadenylic-polyuridylic acid (poly A : U) for locally advanced gastric cancer after curative surgery: final results of 15-year follow-up
Annals Of Oncology 19:520~526,2008


Survival benefit of combined curative resection of the stomach (D2 resection) and liver in gastric cancer patients with liver metastases
Annals Of Oncology 19:1146~1153,2008


Mobilized CD34+ cells as a biomarker candidate for the efficacy of combined maximal tolerance dose and continuous infusional chemotherapy and G-CSF surge in gastric cancer
Cancer Letters 270 2:269~276,2008


절제 불가능한 결장직장암의 원격전이 환자에서 표적치료제를 포함한 선행항암화학요법 후 시행한 근치적인 절제술
대한대장항문학회지 24 3:184~191,2008


Clinical Significance of Margin Status in Postoperative Radiotherapy for Extremity and Truncal Soft-Tissue Sarcoma
International Journal Of Radiation Oncology Biology Physics 70 1:139~144,2008


Phase II study of combination chemotherapy of 5-fluorouracil, low-dose leucovorin, and oxaliplatin (FLOX regimen) in pretreated advanced gastric cancer
Annals Of Oncology 19 6:1135~1140,2008


Prognostic factors affecting oncologic outcomes in patients with locally recurrent rectal cancer: impact of patterns of pelvic recurrence on curative resection
Langenbecks Archives Of Surgery 394:71~77,2009


Association of the ABCB1 gene polymorphisms 2677G > T/A and 3435C > T with clinical outcomes of paclitaxel monotherapy in metastatic breast cancer patients
Annals Of Oncology 20 2:272~277,2009


Postoperative adjuvant chemotherapy of gastric cancer: scrutiny into the clinical evidence based on quality assessment of medical literature of randomized controlled trials
CANCER CHEMOTHERAPY AND PHARMACOLOGY 63 5:919~927,2009


Copy number changes can be a predictor for hemoglobin reduction after S-1 monotherapy in gastric cancer
International Journal Of Oncology 34:787~796,2009


clinical value of ezrin expression in primary osteosarcoma
Cancer Research And Treatment 41 3:138~144,2009


Clinical features and treatment outcomes of advanced stage primary hepatic angiosarcoma
Annals Of Oncology 20 4:780~787,2009


A prospective, multicenter, phase 2 study of imatinib mesylate in Korean patients with metastatic or unresectable gastrointestinal stromal tumor
Oncology 76 5:326~332,2009


Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer
New England Journal Of Medicine 360 14:1408~1417,2009


Cetuximab plus chemotherapy in patients with advanced non-small-cell lung cancer (FLEX): an open-label randomised phase III trial
Lancet 373 9674:1525~1531,2009


A Phase II Feasibility Study of Weekly Paclitaxel in Heavily Pretreated Advanced Gastric Cancer Patients with Poor Performance Status
Oncology 77 6:349~357,2009


Circulating endothelial progenitor cells (EPC) for tumor vasculogenesis in gastric cancer patients
Cancer Letters 288 1:124~132,2010


Two Dosages of Oral Fluoropyrimidine S-1 of 35 and 40 mg/m(2) bid: Comparison of the Pharmacokinetic Profiles in Korean Patients with Advanced Gastric Cancer
JAPANESE JOURNAL OF CLINICAL ONCOLOGY 40 1:29~35,2010


A Phase II Study of a Combined Biweekly Irinotecan and Monthly Cisplatin Treatment for Metastatic or Recurrent Gastric Cancer
American Journal of Clinical Oncology-Cancer Clinical Trials 33 1:56~60,2010


Phase II study of preoperative chemoradiotherapy (CRT) with irinotecan plus S-1 in locally advanced rectal cancer
Radiotherapy And Oncology 95 3:303~307,2010


Adenocarcinoma of the small bowel at a single Korean institute: management and prognosticators
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY 136 3:387~394,2010


Outcomes of multiple salvage chemotherapy for advanced gastric cancer: implications for clinical practice and trial design
CANCER CHEMOTHERAPY AND PHARMACOLOGY 66 4:797~805,2010


A phase I pharmacokinetic and pharmacodynamic study of CKD-732, an antiangiogenic agent, in patients with refractory solid cancer
Investigational New Drugs 28 5:650~658,2010


Chemokine growth-regulated oncogene 1 as a putative biomarker for gastric cancer progression
Cancer Science 101 10:2200~2206,2010


Paclitaxel combined with ifosfamide in anthracycline- and docetaxel-pretreated metastatic breast cancer: activity independence of prior docetaxel resistance
CANCER CHEMOTHERAPY AND PHARMACOLOGY 66 3:425~431,2010


The Clinical Outcome of Chemotherapy-Induced Amenorrhea in Premenopausal Young Patients with Breast Cancer with Long-Term Follow-up
Annals of Surgical Oncology 17 12:3259~3268,2010


Clinicopathologic Features of Metachronous or Synchronous Gastric Cancer Patients with Three or More Primary Sites
Cancer Research and Treatment 42 4:217~224,2010


Brain metastases from colorectal carcinoma: prognostic factors and outcome
JOURNAL OF NEURO-ONCOLOGY 101:49~55,2011


Genome-wide molecular characterization of mucinous colorectal adenocarcinoma using cDNA microarray analysis
ONCOLOGY REPORTS 25 3:717~727,2011


A Randomized Phase 2 Study of Docetaxel and S-1 Versus Docetaxel and Cisplatin in Advanced Gastric Cancer With an Evaluation of SPARC Expression for Personalized Therapy
CANCER 117 10:2050~2057,2011


Predictive values of 5-fluorouracil pathway genes for S-1 treatment in patients with advanced gastric cancer
ANTI-CANCER DRUGS 22 8:801~810,2011




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